11C-Pittsburgh compound B and18F-THK 5351 positron emission tomography brain imaging in cognitively normal individuals
نویسندگان
چکیده
منابع مشابه
Subjective cognition and amyloid deposition imaging: a Pittsburgh Compound B positron emission tomography study in normal elderly individuals.
OBJECTIVE To study the relationship between subjective cognition and the neuropathological hallmark of Alzheimer disease (AD), amyloid-β (Aβ) deposition, using carbon 11-labeled Pittsburgh Compound B (PiB) positron emission tomography in normal elderly individuals. DESIGN Cross-sectional analysis. SUBJECTS Forty-eight cognitively normal elderly subjects (11 with high PiB uptake and 28 with ...
متن کاملComparison of [18F]Flutemetamol and [11C]Pittsburgh Compound-B in cognitively normal young, cognitively normal elderly, and Alzheimer's disease dementia individuals
BACKGROUND Understanding the variation in uptake between different amyloid PET tracers is important to appropriately interpret data using different amyloid tracers. Therefore, we compared the uptake differences in [18F]Flutemetamol (FMT) and [11C]PiB (PiB) PET in the same people. METHODS Structural MRI, FMT PET and PiB PET were each performed in 30 young cognitively normal (yCN), 31 elderly c...
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The accumulation of β-amyloid in the brain is an early event in Alzheimer's disease. This study presents the first patient with Alzheimer's disease who underwent positron emission tomography imaging with the amyloid tracer, Pittsburgh Compound B to visualize fibrillar β-amyloid in the brain. Here we relate the clinical progression, amyloid and functional brain positron emission tomography imagi...
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Prostate cancer remains a major public health problem worldwide. Imaging plays an important role in the assessment of disease at all its clinical phases, including staging, restaging after definitive therapy, evaluation of therapy response, and prognostication. Positron emission tomography with a number of biologically targeted radiotracers has been demonstrated to have potential diagnostic and...
متن کاملEvaluating atypical dementia syndromes using positron emission tomography with carbon 11 labeled Pittsburgh Compound B.
CONTEXT A progressive decline in episodic memory affecting activities of daily living is the usual clinical presentation of Alzheimer disease. However, patients presenting with atypical or focal clinical symptoms such as language or visuospatial dysfunction often pose a diagnostic challenge. OBJECTIVE To explore the presence and topography of beta amyloid (Abeta) as measured by carbon 11-labe...
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ژورنال
عنوان ژورنال: World Journal of Nuclear Medicine
سال: 2020
ISSN: 1450-1147
DOI: 10.4103/wjnm.wjnm_57_20